Infectious Diseases and Immunity

By the end of the course , the student should be able to;                                  

• Classify the microorganisms,

• Classify the bacteria

• Define the main bacterial structure

List the types of culture media,

• Define the inoculation techniques and incubation conditions,

• Define meaning of growth,

• Define the growth curve,

• Define the colony morphology on media,

• Describe microbial metabolism and growth

Define the virulence factors,

• Explain variety of the toxins,

• Define the general immunopathogenesis,

• List the main pathogens for human

Describe the main terms of bacterial genetics,

• Define the organization of genes,

• Define mutation, gene expression, transfer of DNA

Classify Gram positive cocci,

• List the Gram positive cocci,

• Describe important Gram positive cocci,

• Define the general tests for identification of Gram positive cocci,

• Explain the relation between Gram positive cocci and infectious diseases

• List the rules of sterilization of disinfection,

• List and describe the methods for sterilization of disinfection,

• Define the correct method for sterilization and disinfection of each material and equipment

• Classify the Gram negative cocci,

• List the Gram negative cocci,

• Describe the important Gram negative cocci,

• Define the general tests for identification of Gram negative cocci,

• Explain the relation between Gram negative cocci and infectious diseases

Classify the Gram negative bacilli and nonfermenters

• List the Gram negative bacilli and nonfermenters

• Describe the important Gram negative bacilli and nonfermenters

• Define the general tests for identification of Gram negative bacilli and nonfermenters

• Explain the relation between Gram negative bacilli and nonfermenters and infectious diseases

Yersinia, Francisella, Pasteurella, Vibrio, Campylobacter

• Define the diagnosistic and treatment methods for Yersinia, Francisella, Pasteurella, Vibrio,

Campylobacter,

• Explain the epidemiology, prevention and control of these infections.

Antibacterial agents

• Classify the antibacterial agents,

• Explain the mechanisms of action of clinically used antimicrobial drugs,

• Define the resistance to antimicrobial drugs

• Classify Mycobacteria,

• Define the growth and cultivation of Mycobacteria,

• Explain the relation between Mycobacteria and infection diseases, Explain the susceptibility tests of Mycobacteria

Define the diagnosistic and treatment methods for Actinomyces, Nocardia,

• Tell the epidemiology, prevention and control of these infections

Classify the anaerobic bacteria,

• List the anaerobic bacteria,

• Describe the important anaerobic bacteria,

• Define the general tests for identification of anaerobic bacteria,

• Explain the relation between anaerobic bacteria and infection disea Define the diagnosistic and treatment methods for Spirochetes,

• Tell the epidemiology, prevention and control of these infectionsses

• Tell the epidemiology, prevention and control of these infections

Describe the principle of virus structure,

• Classify the DNA viruses,

• Define the diagnosis of DNA viruses,

• Describe the general symptoms caused by DNA viruses,

Describe the principle of virus structure,

• Classify the RNA viruses,

• Define the diagnosis of RNA viruses,

• Describe the general symptoms caused by RNA viruses

Define the general terms in mycology,

• Classify the fungi,

• List the clinically important fungi,

• List and describe the major mycoses and causative fungi,

• Describe the diagnosis of fungal infections,

• Describe the antifungal and treatment

Define the general terms in parasitology,

• Classify the parasites

• List the clinically important parasites,

• List and describe the major parasitic infections,

• Describe the diagnosis of parasitic infections,

• Describe the treatment of parasitic infections

Types of media

• Define the laboratory rules,

• Define the laboratory hazardous class,

• Describe the sample collection and transport methods,

• List the types of microbiological media according to microorganisms

Define the Gram positive and negative bacteria on the microscope

• Explain the difference between Gram positive and negative bacterria

• Define the mycobacteria on the microscope

Explain the microbiological inoculation techniques

• List the main sterilization rules on microbiology laboratory,

• Identify the antibiotics susceptibility testing

• Define the bacterial identification tests

• Describe the methods immunoassay tests

• Define the main nucleic acid techniques

Express the basic information about the immunology lecture program.

• Define the suggested reading for immunology.

• List names and functions of immune system cells.

• Tell briefly the anatomy, structure and function of primary immune organs, such as bone marrow, thymus and secondary immune organs lymph nodes and spleen.

• Explain briefly the lymphatic circulation and cell trafficking.

Tell the development phases of immune cells from stem cell to most mature form.

• Express the general information on cytokine/chemokine interactions at the developmental stage of cells.

• Explain differentiation of eritroid, myeloid and lymhoid cells.

• Differentiate totipotent, multipotent, unipotent hematopoietic cell definitons.

• Make a list of mature forms of immune system cells.

• Explain function of pathogen associated molecular patterns (PAMPs) and pattern recognizing receptors (PRR).

• Explain components and functions of epitelial barriers.

• Tell local and systemic inflammation mechanisms.

• Describe the major features and function of neutrophil, macrophage and NK cells.

• Explain mechanisms related to phagocytosis.

• Tell humoral components of innate immunity and their function.

• Describe the interaction and communication between the innate and adaptive immune system.

Define cells (T and B lymphocyte) of adaptive immune system.

• Describe self tolerance, clonal selection, antigen specific response and immunological memory.

• Tell differences between innate and adaptive immune system.

• Tell role of T and B cells in immune response.

Describe antigen, immunogen and hapten terminology and their differences.

• Explain antigen presentation and processing in general terms.

• Describe structures and subgroups of antibodies.

• Explain antibody mediated immune response.

Name the cells, tissues and mediators of humoral and

• Cellular immunity.

• Explain functional mechanisms of humoral and cellular immune response.

• Describe differences and similarities between humoral and cellular immune response.

• Describe complement system and its proteins.

Explain different hypersensitivity mechanisms.

• Name the tests for hypersensitivity reactions.

• Describe at least one disease name for each type of hypersensitivity reaction

Explain mechanisms and classification of immune deficiencies.

• Describe the criteria for immune deficiencies.

• Tell the necessity of guiding for immunology consultation for patients having frequent infections.

• Explain immune response mechanisms to bacteria, fungus, virus and parasites.

• Define immune escape mechanisms of infectious agents.

• Explain primary and secondary immune response to infectious agents.

• Tell anatomy and cells of oral/mucosal immune system.

• Explain tolerance mechanisms to commensal bacteria.

• Explain protein transport and trans-­‐cytosis through epithelia.

• Describe immune response to pathogenic microorganisms in mucosa.

• Define similarities and differences of mucosal immune response and immune system.

• Tell interaction of cytokines and osteal system.

• Tell basic information about osteoimmunology.

• Recognize erythrocytes, the various leukocytes, and platelets.

• List five types of leukocytes present in peripheral blood and state their respective cell counts.

• Summarize the similarities and chief differences between the five types of leucocytes

• Understand the organization of lymphoid tissue

• Recognize the major unencapsulated collections of lymphocytes in the mucosa-­‐associated lymphoid tissue (MALT).

• Compare the basic histological organization of lymph node, thymus, and tonsil. marrow, thymus and secondary immune organs lymph nodes and spleen.

• Explain briefly the lymphatic circulation and cell trafficking.

Tell the development phases of immune cells from stem cell to most mature form.

• Express the general information on cytokine/chemokine interactions at the developmental stage of cells.

• Explain differentiation of erythroid, myeloid and lymphoid cells.

• Differentiate totipotent, multipotent, unipotent hematopoietic cell definitions.

• Make a list of mature forms of immune Explain humoral and cellular components of innate immune system.

• Explain function of pathogen associated molecular patterns (PAMPs) and pattern recognizing receptors (PRR).

• Explain components and functions of epithelial barriers.

• Tell local and systemic inflammation mechanisms.

• Describe the major features and function of neutrophil, macrophage and NK cells.

• Explain mechanisms related to phagocytosis.

• Tell humoral components of innate immunity and their function.

• Describe the interaction and communication between the innate and adaptive immune system.system cells.

• Define cells (T and B lymphocyte) of adaptive immune system.

• Describe self tolerance, clonal selection, antigen specific response and immunological memory.

• Tell differences between innate and adaptive immune system.

• Tell role of T and B cells in immune response.

• Describe antigen, immunogen and hapten terminology and their differences.

• Explain antigen presentation and processing in general terms.

• Describe structures and subgroups of antibodies.

• Explain antibody mediated immune response.

• Name the cells, tissues and mediators of humoral and

• Cellular immuni Explain functional mechanisms of humoral and cellular immune response.

• Describe differences and similarities between humoral and cellular immune response.

• Describe complement system and its proteins.

• Explain different hypersensitivity mechanisms.

• Name the tests for hypersensitivity reactions.

• Describe at least one disease name for each type of hypersensitivity reaction.

• Explain mechanisms and classification of immune deficiencies.

• Describe the criteria for immune deficiencies.

• Tell the necessity of guiding for immunology consultation for patients having frequent infections.

• Explain immune response mechanisms to bacteria, fungus, virus and parasites.

• Define immune escape mechanisms of infectious agents.

• Explain primary and secondary immune response to infectious agents.

• Tell anatomy and cells of oral/mucosal immune system.

• Explain tolerance mechanisms to commensal bacteria.

• Explain protein transport and trans-­‐cytosis through epithelia.

• Describe immune response to pathogenic microorganisms in mucosa.

• Define similarities and differences of mucosal immune response and immune system.

• Tell interaction of cytokines and osteal system.

• Tell basic information about osteoimmunology.

• Recognize erythrocytes, the various leukocytes, and platelets.

• List five types of leukocytes present in peripheral blood and state their respective cell counts.

• Summarize the similarities and chief differences between the five types of leucocytes

• Understand the organization of lymphoid tissue

• Recognize the major unencapsulated collections of lymphocytes in the mucosa-­‐associated lymphoid tissue (MALT).ty.

• Compare the basic histological organization of lymph node, thymus, and tonsil.

• Explain the function of the tonsills, lymph nodes and thymus.

Histology of Skin, Epiglottis and Lymph Organs

• Draw a labeled diagram of the skin and its associated components.

• Draw a labeled diagram of the epiglottis.

• Draw a labeled diagram of the lymph node and thymus.

• Identify histological specification of skin, epiglottis, lymph node and thymus.

PRACTICAL COURSE CONTENT  * FALL