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Course Code: 
MDD 192
Course Period: 
Spring
Course Type: 
Core
Credits: 
0
ECTS: 
8
Course Language: 
English
Course Objectives: 
This course is conducted with the collaboration of the departments of Medical Biology, Biophysics, Histology and Embryology, Physiology and Anatomy. The course aims to familiarize the student with the 4 basic tissue systems
Course Content: 

The course encompasses topics such as Histology of Covering Epithelium, Histology of Glandular Epithelium, Histology of Muscle Tissue, Histology of Connective Tissue, Histology of Cartilage and Bone Tissue, Histology of Epithelial Tissue, Histology of Muscle Tissue, Histology of Connective Tissue, Thorax and vertebral column, Muscles, general consideration, Upper limb, Lower limb, Extracellular matrix. Chromosome analysis, Radiation Biophysics: Nucleus and Radioactivity, The Decay Law of Radioactivity, Physical Half Life,Decay Curve, Radiation Biophysics: Particle Radiation (α, β, γ particles), Photoelectric Action, Compton Action, Pair Formation; Half Value Thickness, Radiation Biophysics, Biothermodynamics, laws of thermodynamics, biological energy flow

Course Methodology: 
1: Lecture, 2: Question-Answer, 3: Discussion, 4: Practice
Course Evaluation Methods: 
A: Testing, B: lab study

Vertical Tabs

Course Learning Outcomes

 

Learning Outcomes  Programme learning outcomes Teaching Methods  Assessment Methods 
Relate the structure of three different types of epithelial membranes to their main functions

State two cell renewal mechanisms found in epithelial membranes

Summarize the structure and function of four different types of cell junctions

State what is meant by a basement membrane and discuss it; distinctive composition.

PLO 9,15 1, 2, 3, 4,  A, B
Understand the histological basis on which glands are classified

Differentiate between serous, mucous, and mixed secretory units in sections

State three major differences between exocrine and endocrine gland

PLO 9,15 1, 2, 3, 4,  A, B
Summarize the main similarities and differences between three different types of muscle

Depict how a sarcomere's filaments axe arranged a) during relaxation and b) during

contraction, relating muscle striations to the sarcomere

Draw a labeled diagram of a motor end plate

Explain how contraction is elicited in skeletal muscles

Discuss why certain cell junctions exist between some muscle cells but not others

Elaborate on which types of muscle can regenerate

PLO 9,15 1, 2, 3, 4,  A, B
Summarize the main structure similarities and differences between collagen and elastin

Explain the histologic changes associated with edema

Differentiate between six different cell types present in loose connective tissue

Discuss the functional significance of macrophage derived inflammatory cells and its

location,

Outline how the structure of plasma cells reflects their chief function

Discuss the functional significance of four mast cell-derived inflammatory mediators

Distinguish loose and dense connective tissue using the light microscope

PLO 9,15 1, 2, 3, 4,  A, B
Name body sites where each form of dense ordinary connective tissue is found.

Outline the chief similarities and differences between bone and cartilage, and specify the

subtypes of each tissue

Outline the two different ways by which bones develop.

Discuss the structural and functional differences between osteoblasts and osteoclast

Recognize the four constituent zones and diaphyseal trabeculae of an epiphyseal plate

and state respective functional significance.

Distinguish between sites of bone growth and sites of bone resorption

PLO 9,15 1, 2, 3, 4,  A, B
Recognize eight epithelial subtypes.

Draw a labeled diagram of the simple squamous, simple cuboidal, simple columnar stratified squamous, pseudostratified and transitional epithelium.

PLO 9,15 1, 2, 3, 4, A, B
Recognize three muscle subtypes.

Draw a labeled diagram of the skeletal, hearth, and smooth muscle

PLO 9,15 1, 2, 3, 4, A, B
Recognize connective tissue proper subtypes.

Draw a labeled diagram of the loose connective tissue, dense irregular connective tissue, dense regular connective tissue, and adipose tissue

PLO 9,15 1, 2, 3, 4, A, B
List the Thoracic bones with their joints.

Describe the general characteristics of each vertebrate.

Define the differences between cervical,thoracic and sacral vertebrates.

Explain the major characteristics of coxae, sacrum and coccyx.

List the atypical bones of the ribs and vertebral column with their reasons.

PLO 9,15 1, 2, 3, 4, A, B
List the different types of muscles.

Explain the general characteristics of the insertionand origin in addition to contraction types.

Define the tendons and muscle reflexes.

Explain the general considerations of muscleinnervation.

PLO 9,15 1, 2, 3, 4, A, B
List the muscles and the bones of the upper limb.

Describe the general anatomy of each upper limb bone.

Explain the general characteristics of the upper limb musclesʼ innervation and functions.

Define the vasculature of the upper limb.

Explain the brachial plexus.

 Define the dermatomes of the upper limb.

PLO 9,15 1, 2, 3, 4, A, B
List the muscles and the bones of the lower limb.

Describe the general anatomy of each lower limbbone.

Explain the general characteristics of the lower limbmusclesʼ innervation and functions.

Define the vasculature of the lower limb.

Explain the lumbosacral plexus.

Define the dermatomes of the lower limb.

PLO 9,15 1, 2, 3, 4, A, B
Evaluate the atom structure knowledge on recall,

Reconcile the isotope related knowledge of atom and Rutherford’s experiments on recall

Distinguish chemical and nuclear reaction subjects

Explain the hypotheses related to reasons of nuclear reactions

Explain the Law of Radioactive Decay

Explain the conception of Physical Half--‐Life.

Explain the Decay curve and illustrate examples related to its applications

PLO 9,15 1, 2, 3, 4, A, B
List the properties of gamma and particle radiations

List the properties of alpha particle radiation with some radiation reaction examples

 List the properties of beta particle radiation with some radiation reaction examples

List the sources of the particles according to their medical importance

List the properties of gamma radiation

Explain the importance of gamma radiation for nuclear reactions

Explain the mechanisms of gamma radiation and a matter interaction effects

PLO 9,15 1, 2, 3, 4, A, B
Define the absorption and total absorption coefficients

Explain the Absorption Law of gamma radiation

Explain the “Half value thickness” conception

Define the variables (sort of materials and energy of incident radiation) the “Half value thickness” parameter depends on

PLO 9,15 1, 2, 3, 4, A, B
List the similarities and differences between gamma and x--‐radiations including the fields of their applications

List and define the units of radioactivity

List the 8 isotopes (tritium, carbon14, crypton85, stronsium90, iodine, cesium and plutonium)

Describe the application fields and methods of each of the isotopes

 Differentiate the radioisotopes according to stable component existence in their content

Radiation Biophysics: Biological Mechanisms of Radiation,Radiation Safety, Inverse Square Rule

Define the ionization and excitation properties of nuclear radiations

PLO 9,15 1, 2, 3, 4, A, B
Tell about the toxic free radical formation mechanisms from the point of the properties.

Explain the “Linear energy transfer”, “Ionization number” and “Specific ionization” conceptions.

Explain the “Reaching distance” conception.

Distinguish and define direct and indirect effects dependent on physical interaction durations

Explain the radiation biological effects up today theories

List the radiation effects on human organism

Evaluate the effects of radiations with and without threshold

 Describe the radiation caused diseases

List the radiation sources and explain the ways of radiation influences

 Evaluate Legally Permitted Radiation Dosages

Evaluate the danger based radiation classification

Tell time and distance (inverse square law) related radiation effects

Lasers in Medicine

Tell about laser beam generation fundamental principles

Describe the laser beam properties and differences from those of light

 Distinguish lasers according to their working principles

Explain the pulse laser generation mechanisms

 Explain the permanent laser (Helium--‐neon laser) generation mechanisms

List the fields of industry and medicine laser uses are implemented in

PLO 9,15 1, 2, 3, 4, A, B
Explain “Energy” conception and types (chemical, electric and mechanic energies)

 Define the subjects of Bioenergetics and bio--‐thermodynamics

List the parameters of physical thermodynamic systems

Explain the Zeroth Law of thermodynamics

Explain the First Law of thermodynamics

Explain the general differential expression of the First Law

Describe the connections between the First Law and the Law of Energy Conservation and Conversion

PLO 9,15 1, 2, 3, 4, A, B
Explain the structures of monosaccharides, oligosaccharides, polysaccharides

Define monosaccharide derivatives  

Explain the structure of starch and glycogen

List the components of glycosaminoglycans

Explain the functions of glycosaminoglycans

Define the structure of saturated and unsaturated fatty acids

Define the structure of triacylglycerols, glycerophospholipids, sphingolipids 

Explain the function of bile acids

Explain the function of eicosanoids

Define structure of glutathione

Explain antioxidant system of human body

Explain the protein structure: Primary, secondary, tertiary and quaternary structures

PLO 9,15 1, 2, 3, 4, A, B
Explain the First Law applied to isothermal processes of Ideal gas

Explain the First Law applied to the adiabatic processes Ideal gas

Define the resemblance and differences between adiabatic and isothermal processes

Explain the graphical version of the resemblances and differences between adiabatic and isothermal processes

Explain the different versions of the First Law adiabatic processes

PLO 9,15 1, 2, 3, 4, A, B
Define the fundamental principles of the Second Law of thermodynamics

 Define the conception of “Entropy”

 Explain the mathematical expression and units of entropy

Explain the conception of “Entropy” on examples

Define the conceptions “Standard Absolute Entropy” and “Entropy of Reaction”

List the entropy related parameters

Define “Free Energy” conception far a system

 Explain the mathematical connection between changes of entropy and free energy

Describe the connection for a thermodynamic system

PLO 9,15 1, 2, 3, 4, A, B
Describe the natural flow of biologic energy

• Define the events of Photosynthesis and Respiration and their connections

• Describe the Enthalpy, Free Energy and Entropy relationships in the contexts of

photosynthesis and respiration

Define free energy change concerned one mole of ATP

Describe the differences between energy transformations for thermodynamic physical and biological systems

Define the anabolic and catabolic reactions

Evaluate the controlled implementation of energetic processes in living cells

Distinguish the change differences between Standard Free Energy and Free Energy in biological systems

Describe the connection between Free Energy Change and Reduction Potential

PLO 9,15 1, 2, 3, 4, A, B

Course Flow

THEORETICAL COURSE CONTENT  SPRING

 

COURSE CONTENT (1.semester)  
Week  Theoretical Topics                                       Study Materials
1 Histology of covering and glandular epithelium Recommended resources 
2 Histology of muscle and connective tissue Recommended resources 
3 Histology of cartilage and bone tissue Recommended resources 
4 Histology of epithelial, muscle and connective tissue Recommended resources 
5 Histology of thorax and vertebral column  Recommended resources 
6 Muscles, general considerations Recommended resources 
7 Upper limb, lower limb, Extracellular matrix Recommended resources 
8 Radiation biophysics Recommended resources 
9 Thermodynamics Recommended resources 
       

 

 

 

 

PRACTICAL COURSE CONTENT  * SPRING

COURSE CONTENT (1.semester)  
Week  Practical Topics                                       Study Materials
1 Lab studies  Recommended resources 
2 Lab studies  Recommended resources 
3 Lab studies  Recommended resources 
4 Lab studies  Recommended resources 
5 Lab studies  Recommended resources 
6 Lab studies  Recommended resources 
7 Lab studies  Recommended resources 

Recommended Sources

 

RECOMMENDED SOURCES
Textbook 1.Netter's Head and Neck Anatomy for Dentistry

Neil S. Norton ISBN: 9781929007882

2.Wheeler's Dental Anatomy, Physiology and Occlusion

Major M.Ash. Stanley Nelson Elsevier Health Sciences

3.Head and Neck Anatomy for Dental Medicine

Baker / Schuenke / Schulte / Schumacher

Paperback / softback ISBN (Americas): 9781604062090

4.3D Head and Neck Anatomy for Dentistry

PrimalPictures http://www.learnerstv.com/Free-Dental-Video-lectures-ltv137-Page1.htm

5. Biophysics, an Introduction Rodney M.J. Cotterill,England,2005

6. Biological physics, Philip C. Nelson, New York, 2004

Additional Resources

- Lecture notes

 

Material Sharing

 

MATERIAL SHARING
Documents Photocopy shareable.
Assignments Sharable.
Exams Not shareable.

Assessment

 

ASSESSMENT
IN-TERM STUDIES NUMBER PERCENTAGE
Midterm Exam 1 50
Quiz - -
Homework - -
Total   50
CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE   50
CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE   50
Total   100

 

COURSE CATEGORY Selective

Course’s Contribution to Program

 

COURSE'S CONTRIBUTION TO PROGRAM
No Program Learning Outcomes Contribution
1 2 3 4 5  
9 Integrating basic medical sciences in clinical sciences and using this information in all procedures of the patient.         X  
15 Following international literature, evaluating publications critically and integration of research results and evidence based dentistry during practice.         X  

ECTS

 

Activity  NUMBER  Duration
(Hours )
Total workload
(Hours )
Course duration  1st semester   ( theoretical)  7 8.9 62
Course duration  1st semester   ( practical ) 7 4 28
Studies outside the class  ( 1st semester )  7 15 105
TOTAL      195
Total workload /25     7.8
ECTS credits of the course      8