The course includes topics such as Renal Circulation and Glomerular Functions, Tubular Functions & Micturition, Fluid and Electrolyte Balance, Regulation of Acid-‐Base Balance, Introduction to Endocrinology, Pituitary Gland and Hypothalamic Control, Thyroid Metabolic Hormones, Adrenocortical Hormones, Hormonal Regulation of Bone Turnover, Insulin, Glucagon & Regulation of Blood Glucose, Male Reproductive Physiology, Female Reproductive Physiology, Pregnancy and Lactation, Glomerular Functions and Hormone Action, Histology of Urinary System, Histology of Endocrine System, Histology of Urinary and Endocrine System, Endocrine glands, Kidneys, ureters, urinary bladder and urethra and male and female genital organs. |
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Course Learning Outcomes
Language of Instruction | English |
Course Level | Undergraduate |
Course Type | Compulsory |
Course Coordinator
Vice Coordinator |
Prof. İnci Özden
Assist.Prof.Dr. Müge Kopuz Alvarez Noval |
Instructors |
Prof.Dr. Mehtap Kaçar,MD,PhD
Assoc.Prof.Dr. Aylin Yaba Uçar,PhD Assist.Prof.Dr.Alev Cumbul ,PhD Assist.Prof.Dr. Uğur Baran Kasırga,MD |
Assistants | - |
Goals | This course is conducted with the collaboration of the departments of Physiology, Anatomy, and Histology and Embryology. The course aims to familiarize the student with the functions and principles of endocrine and urogenital systems. |
Content | The course includes topics such as Renal Circulation and Glomerular Functions, Tubular Functions & Micturition, Fluid and Electrolyte Balance, Regulation of Acid-‐Base Balance, Introduction to Endocrinology, Pituitary Gland and Hypothalamic Control, Thyroid Metabolic Hormones, Adrenocortical Hormones, Hormonal Regulation of Bone Turnover, Insulin, Glucagon & Regulation of Blood Glucose, Male Reproductive Physiology, Female Reproductive Physiology, Pregnancy and Lactation, Glomerular Functions and Hormone Action, Histology of Urinary System, Histology of Endocrine System, Histology of Urinary and Endocrine System, Endocrine glands, Kidneys, ureters, urinary bladder and urethra and male and female genital organs. |
Learning Outcomes | Programme learning outcomes | Teaching Methods | Assessment Methods |
Define the functions of kidneys
Define the functional anatomy of the kidneys and renal circulation Explain the physiology of renal blood flow. Define glomerular filtration. Explain the mechanisms involved in the regulation of renal function Define the composition of glomerular ultrafiltrate and explain how it is produced. |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Define tubular functions
Explain how the proximal convoluted tubule reabsorbs salt and water. Define active transport and osmosis in the loop of Henle Explain the vasa recta function Define urinary bladder and smooth muscle contraction Explain micturition and mechanisms Define micturition reflex Explain causes of incontinence and retention |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Explain the function, distribution and physiological importance of sodium, potassium, magnesium, calcium and phosphate ions
Define osmotic pressure Explain the regulation of osmolarity |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Describe acid-‐base chemistry using the Henderson-‐Hasselbalch equation
Define the buffer mechanisms and explain their relevant roles in the body Explain the regulation of acid-‐base balance Explain the principles of blood gas and acid-‐base analysis |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Define hormone and endocrine secretion
Describe hormones according to their chemical structures and give examples Explain hormone secretion and control mechanisms Define hormone transportation mechanisms in blood |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Define the structure of the pituitary gland and explain the functional relationship between the pituitary and the hypothalamus.
Explain the role of the hypothalamus in the integration of neuro-‐humoral responses Explain the control of secretion and the functions of pituitary hormones List the hormones released by the posterior pituitary, |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Describe the structure of thyroid gland
Define the synthesis and functions of thyroid hormones Explain how the thyroid hormones secretion is regulated Define thyroid disorders and diseases |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Define parts of the adrenal gland
Define the types and actions of corticosteroids Define the control of secretion and the functions of adreno-‐cortical hormones Explain disorders and diseases of the adrenal gland |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Define the location of the parathyroid glands
Explain the actions of PTH and the regulation of its secretion. Define the actions of calcitonin and the regulation of its secretion. Explain synthesis and role of vitamin D in bone mineralization |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Explain why the pancreas is both an exocrine and an endocrine gland
Define the actions of pancreatic hormones Explain the control of blood glucose levels Define pathogenesis of type I and II diabetes mellitus |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Define components and functions of male reproductive system
Explain spermatogenesis and hypothalamo-‐hypophyseal control mechanisms Explain functions and and hormonal control mechanisms of testosterone Define male reproductive system disorders and diseases such as infertility and prostate hyperplasia |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Define components and functions of female reproductive system
Explain oogenesis and hypothalamo-‐hypophyseal control mechanisms Define monthly menstruel cycle and ovarian and uterine changes Define menopause and hormonal changes |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Define hormonal changes during pregnancy
Explain metabolic changes in the mother during pregnancy Define functions of plasenta Define labor process and hormonal control of myometrial contractions Define lactation and hormonal factors involved |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Perform and interpret the experiment concerning glomerular functions and hormone action | PLO 9,15 | 1, 2, 3, 4, | A, B |
Specify the glomerular components that produce the urinary filtrate, outlining the role of each component
Name five major segments of the nephron and summarize the chief functions of each segment State where juxtaglomerular cells are situated and discuss their functional importanceSpecify the lining epithelium and arrangement of smooch muscle in the urinary passages and bladder |
PLO 9,15 | 1, 2, 3, 4, | A, B |
State two functional consequences of surgical damage to the connection between thehypothalamus and the pituitary
Recognize chromophils in the pituitary and list the hormones they produce Outline how thyroid hormone is produced by thyroid follicular epithelial cells Name two hormones that regulate osteoclast activity and summarize their action |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Summarize with a labeled diagram the structural organization of a renal corpuscle
Draw a labeled diagram of a thyroid and an adrenal gland showing the sites of production of all hormones Identify histological specification of kidney, thyroid and adrenal gland. |
PLO 9,15 | 1, 2, 3, 4, | A, B |
List the layers, neighbourhoods,innervation, lymphatics and vasculature of the Suprarenal glands.
List the innervation,lymphatics,vasculature of the Thyroid and parathyroid organs in addition to their neighbourhoods. Tell the examples of the anatomical complications of the thyroid masses’ compressions and the thyroid and parathyroid surgeries. Define the surface landmarks for to tap the nerve for to check the Chvostek sign. Explain the neighbourhoods of the Thymus in addition to its lymphatics and vasculature. |
PLO 9,15 | 1, 2, 3, 4, | A, B |
List the anterior and posterior relationships of the right and the left kidneys.
Define the layers, innervation, vasculature and lymphatics of the kidneys. List the fascias, fatty tissues and muscles from skin to kidney in the correct order. Explain the parts of the uretries, in addition to crosses with other anatomical structures, vascularization and lymphatics. Define the 3 faced pyramidal shape of the bladder, in addition to its muscular wall,vasculature and lymphatics. Explain the innervation of the bladder and therby the micturition functional anatomy. Define the parts of the urethra with their neighbourhood organs and surrounding glands, in addition to lymphatics and vasculature. Explain the lymphatics, vasculature,innervation and the parts of the Prostate gland. |
PLO 9,15 | 1, 2, 3, 4, | A, B |
List the Pelvic and the pelvic diaphragm muscles and their innervation and vasculature.
List the internal and external organs of the male genital system. Explain the innervation,lymphatics and vasculature of the Penis and the scrotum. List the layers of the scrotum and the fascias of the Scrotum and the penis with their elongating origins in the abdominal region. List the female internal and external organs. Explain the innervation, lymphatics and vasculature of the uterus,ovaries, Fallopian tubes cervix,vagina, clitoris and the labiums. List the ligaments that stabilize and surrounds the uterus and ovaries and their contents. Define the glands of the female genital system with their opening levels. Define the borders of the Perineum, Urogenital and Anal triangle. List the deep and superficial perineal pouch with its borders and contents. |
PLO 9,15 | 1, 2, 3, 4, | A, B |
Course Flow
THEORETICAL COURSE CONTENT *SPRING
COURSE CONTENT (4th.semester) | |||
Week | Theoretical Topics | Study Materials | |
1 | Renal Circulation and Glomerular Functions, Tubular Functions & Micturition, Fluid and Electrolyte Balance, Regulation of Acid-‐Base Balance, | Recommended resources | |
2 | Introduction to Endocrinology, Pituitary Gland and Hypothalamic Control, Thyroid Metabolic Hormones, Adrenocortical Hormones, , | Recommended resources | |
3 | Hormonal Regulation of Bone Turnover, Insulin, Glucagon & Regulation of Blood Glucose | Recommended resources | |
4 | Male Reproductive Physiology, Female Reproductive Physiology, Pregnancy and Lactation | Recommended resources | |
5 | Glomerular Functions and Hormone Action, Histology of Urinary System, Histology of Endocrine System | Recommended resources | |
6 | Histology of Urinary and Endocrine System, Endocrine glands, Kidneys, ureters, urinary bladder and urethra and male and female genital organs. | Recommended resources | |
PRACTICAL COURSE CONTENT * SPRING
COURSE CONTENT (1.semester) | |||
Week | Practical Topics | Study Materials | |
1 | Lab studies | Recommended resources | |
2 | Lab studies | Recommended resources | |
3 | Lab studies | Recommended resources | |
4 | Lab studies | Recommended resources | |
5 | Lab studies | Recommended resources | |
6 | Lab studies | Recommended resources |
Recommended Sources
Textbook |
1. Human Physiology Stuart Ira Fox 10th Edition
Publisher: McGraw Hill 2. Textbook of Medical Physiology Guyton & Hall 12th Edition Publisher: Elsevier & Saunders 3. Anthony Mescher, Basic histology: text and atlas, 12. edition, McGraw--‐Hill Medical (2009). 4. Abraham L. Kierszenbaum A.L., Histology and cell biology: an introduction to pathology, Third Edition, Mosby (2011). 5 . B.K.B. Berkovitz, G.R. Holland, B.J. Moxham, Oral Anatomy, Histology and Embryology, 4. editions, Mosby (2009). 6. James K. Avery, Daniel J. Chiego, Essentials of Oral Histology and Embryology: A Clinical Approach, 3. editions, Mosby (2005). 7.Netter's Head and Neck Anatomy for Dentistry Neil S. Norton ISBN: 9781929007882 8.Wheeler's Dental Anatomy, Physiology and Occlusion Major M.Ash. Stanley Nelson Elsevier Health Sciences 9.Head and Neck Anatomy for Dental Medicine Baker / Schuenke / Schulte / Schumacher Paperback / softback ISBN (Americas): 9781604062090 10.3D Head and Neck Anatomy for Dentistry PrimalPictures |
Additional Resources |
- Lecture notes
|
Material Sharing
MATERIAL SHARING | |
Documents | Photocopy shareable. |
Assignments | Sharable. |
Exams | Not shareable. |
Assessment
ASSESSMENT | ||
IN-TERM STUDIES | NUMBER | PERCENTAGE |
Midterm Exam | 1 | 50 |
Quiz | - | - |
Homework | - | - |
Total | 50 | |
CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE | 50 | |
CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE | 50 | |
Total | 100 |
Course’s Contribution to Program
COURSE'S CONTRIBUTION TO PROGRAM | |||||||
No | Program Learning Outcomes | Contribution | |||||
1 | 2 | 3 | 4 | 5 | |||
9 | Integrating basic medical sciences in clinical sciences and using this information in all procedures of the patient. | X | |||||
15 | Following international literature, evaluating publications critically and integration of research results and evidence based dentistry during practice. | X |
ECTS
Activity | NUMBER |
Duration (Hours ) |
Total workload (Hours ) |
Course duration 1st semester ( theoretical) | 6 | 5.5 | 33 |
Course duration 1st semester ( practical ) | 6 | 2 | 12 |
Studies outside the class ( 1st semester ) | 6 | 15 | 80 |
TOTAL | 125 | ||
Total workload /25 | 5 | ||
ECTS credits of the course | 5 |